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KMID : 0376219710080010085
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Chonnam Medical Journal
1971 Volume.8 No. 1 p.85 ~ p.95
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Modification of Pressor Effects of Norepinephrine by intraventricular Administration of Reserpine, Syrosingopine, and Tetrabenazine.
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Abstract
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1. Modification by intraventricular administration of reserpine, syrosingopine, and tetrabenazine of pressor effect of norepinephrine (NE), epinephrine (EP), angiotensin, and tyramine was investigated in rabbits.
2. Reserpine, doses of 1, 4, 20, 100μg/kg, produced significant increase of pressor effect of NE and EP. Reserpine did not modify the effect of angiotensin and tyramine, except that 100 μg/kg produced increase of -the effect of angiotensin, though it was not significant.
3, Syrosingopine, 4μg/kg, did not potentiate the effect of the above pressor substances, but increasing the doses (20 and 100 ug/kg) potentiated the effect of NE and EP.
4. Tetrabenazine, 0.2 mg/kg, did not produce potentiation, but 1 mg/kg produced potentiating effect on NE and EP.
5. The onset of potentiation of the pressor effect of NE and EP was seen within 30 min, and reached maximum in 60 to 120 min.
6. Carbachol injection inhibited full development of the potentiation of NE effect due to intraventricular injection of syrosingopine.
7. The above results do nit give any information on the mechanism of development of supersensitivity to NE, but these suggest that, the mechanism is not associated with the catecholamine content of the brain and Peripheral tissues, and that the development of supersensitivity is, in some unknown way, related to direct action of reserpine, syrosingopine, and tetrabenazine on the brain tissues.
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